Metoclopramide is a specific blocker of dophamin and serotonin receptors. It has anti-vomiting, soothes hiccup, stimulates and regulates work of gastrointestinal tract. Tone and motor activity of the digestive organs enhance. Secretion of stomach does not change. There are notifications that this medication promotes healing of ulcers in stomach and duodenum. Metoclopramide is used as anti-vomiting drug, nausea caused by narcosis, radiotherapy, side effects of different medications (medications on basis of foxglove, cytostatic drugs: ones to suppress cell division, antibiotics etc.), diet violations, gastroesophageal reflux disease (GERD), diabetic gastroparesis (delayed gastric emptying).
Dosage and directions
To treat GERD Metoclopramide in adults is usually taken four times a day by 10-15 mg, 30 minutes before each meal. For treatment of Gastroparesis 10 mg of Metoclopramide are administered orally four times daily, 30 minutes before each meal and at bedtime. The tabs should be swallowed without chewing with a big quantity of water.
Avoid drinking alcoholic beverages. Do not stop taking this medication without your doctor’s permission and do not take it in qualities larger than prescribed to you. Inform your doctor about all medications and herbal products you use.
Hypersensitivity, when this medication is injected ability to concentrate on driving and operating machinery may decrease as Metoclopramide affects ability to high concentration of attention. Cautiousness should be experienced in patients with bleeding or blockage in the stomach or intestines, epilepsy or other seizure disorder, or an adrenal gland tumor (pheochromocytoma), kidney or liver disease, congestive heart failure, diabetes, or a history of depression children younger than 14 y.o.
Possible side effect
Besides signs of allergy (hives, swelling of tongue, face and rash) side effects may appear as tremors, or restless muscle movements in your eyes, tongue, drowsiness, restlessness, tremor, fatigue, anxiety, insomnia, depression, seizures, fever, stiff muscles, confusion, sweating, jaundice, depression. If you experience this stop taking Metoclopramide and seek for immediate medical help.
Metoclopramide is able to change absorption and effects of other drugs that are absorbed in the small intestine. It accelerates effects of alcohol, diazepam (Valium) and cyclosporine, decreases the concentrations in blood of digoxin (Lanoxin) and cimetidine (Tagamet). Metoclopramide is contraindicated to administer in patients who are treated with MAO inhibitors: isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), selegiline (Eldepryl), and procarbazine (Matulane). Co-administration of anticholinergic drugs can decrease the effectiveness of Metoclopramide. Other medications may also interact wit Metoclopramide: bronchodilators, atropine, cyclosporine, digoxin, acetaminophen.
If you missed a dose take it the soonest. If it is almost time of your next dose just skip it and return to your regular dosage schedule.
Symptoms of overdose may include drowsiness, confusion, tremors or uncontrolled muscle movements in face or neck, or seizure. If you think that took too much of Metoclopramide and experience symptoms listed above contact your doctor immediately, you may need a medical help.
Store at room temperature between 59-77 F (15-25 C) away from light and moisture, kids and pets.
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